| 2022-04-24 15:00:21April 24, 2022 |  Ma-Indies Ladies vs Mamelodi Sundowns Ladies  | 1 - 2 | Hollywoodbets Super League | Peter Mokaba Stadium |
| 2022-05-01 11:30:26May 1, 2022 | Mamelodi Sundowns Ladies v.s Golden Ladies  | 11 - 0 | Hollywoodbets Super League | TUT Pretoria Stadium |
| 2022-05-07 13:00:19May 7, 2022 |  Durban Ladies v.s Mamelodi Sundowns Ladies F.C | 0 - 5 | Hollywoodbets Super League | Chatsworth Stadium |
| 2022-05-11 15:00:37May 11, 2022 | Mamelodi Sundowns Ladies v.s City Lads  | 7 - 1 | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-05-15 15:00:29May 15, 2022 |  UWC v.s Mamelodi Sundowns Ladies | 2 - 0 | Hollywoodbets Super League | University of Western Cape Stadium |
| 2022-05-22 11:30:03May 22, 2022 | Mamelodi Sundowns Ladies v.s TUT Football Club  | 5 - 1 | Hollywoodbets Super League | Wits Stadium |
| 2022-05-28 15:00:02May 28, 2022 |  Thunderbirds Ladies v.s Mamelodi Sundowns Ladies | 1 - 6 | Hollywoodbets Super League | Jan Smuts Stadium |
| 2022-06-01 15:00:31June 1, 2022 | Mamelodi Sundowns Ladies v.s Bloemfontein Celtic F.C  | 2 - 0 | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-06-04 15:00:19June 4, 2022 | Mamelodi Sundowns Ladies v.s JVW F.C  | 4 - 2 | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-06-08 15:00:52June 8, 2022 |  First Touch F.C v.s Mamelodi Sundowns Ladies | 0 - 4 | Hollywoodbets Super League | |
| 2022-06-11 15:00:41June 11, 2022 | Mamelodi Sundowns Ladies v.s Coal City Wizards  | 15:00:413:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-06-25 15:00:29June 25, 2022 |  Vasco da Gama v.s Mamelodi Sundowns Ladies | 15:00:293:00 pm | Hollywoodbets Super League | Parow Park Stadium |
| 2022-08-18 15:00:06August 18, 2022 | Golden Ladies v.s Mamelodi Sundowns Ladies | 15:00:063:00 pm | Hollywoodbets Super League | North West University Stadium |
| 2022-08-21 15:00:22August 21, 2022 | Mamelodi Sundowns Ladies v.s Durban Ladies F.C | 15:00:223:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-08-24 15:00:39August 24, 2022 |  Tsunami Queens F.C v.s Mamelodi Sundowns Ladies | 15:00:393:00 pm | Hollywoodbets Super League | Goblerpark Stadium, Bethlehem |
| 2022-08-27 15:00:38August 27, 2022 | City Lads v.s Mamelodi Sundowns Ladies | 15:00:383:00 pm | Hollywoodbets Super League | Isaac Wolfson Stadium |
| 2022-09-17 15:00:31September 17, 2022 | Mamelodi Sundowns Ladies v.s UWC | 15:00:313:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-09-21 15:00:18September 21, 2022 | Mamelodi Sundowns Ladies v.s Ma-Indies Ladies | 15:00:183:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-09-24 15:00:09September 24, 2022 | TUT Football Club v.s Mamelodi Sundowns Ladies | 15:00:093:00 pm | Hollywoodbets Super League | TUT Pretoria Stadium |
| 2022-09-28 15:00:19September 28, 2022 | Mamelodi Sundowns Ladies v.s Thunderbirds Ladies | 15:00:193:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-10-02 15:00:11October 2, 2022 | Bloemfontein Celtic F.C v.s Mamelodi Sundowns Ladies | 15:00:113:00 pm | Hollywoodbets Super League | Central University of Technology |
| 2022-10-16 15:00:07October 16, 2022 | JVW F.C v.s Mamelodi Sundowns Ladies | 15:00:073:00 pm | Hollywoodbets Super League | Wits Stadium |
| 2022-10-22 15:00:48October 22, 2022 | Mamelodi Sundowns Ladies v.s First Touch F.C | 15:00:483:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-10-26 15:00:18October 26, 2022 | Coal City Wizards v.s Mamelodi Sundowns Ladies | 15:00:183:00 pm | Hollywoodbets Super League | Puma Stadium |
| 2022-11-06 15:00:10November 6, 2022 | Mamelodi Sundowns Ladies v.s Vasco da Gama | 15:00:103:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-11-13 15:00:59November 13, 2022 |  University of JHB F.C v.s Mamelodi Sundowns Ladies | 15:00:593:00 pm | Hollywoodbets Super League | UJ Soweto soccer stadium |
| 2022-11-20 15:00:45November 20, 2022 | Mamelodi Sundowns Ladies v.s Tsunami Queens | 15:00:453:00 pm | Hollywoodbets Super League | Lucas Moripe Stadium |
| 2022-11-27 15:00:16November 27, 2022 |  Richmond United v.s Mamelodi Sundowns Ladies | 15:00:163:00 pm | Hollywoodbets Super League | Merino Park Stadium, De Aar |
