Mamelodi Sundowns travelled to the Mother City to take on Stellenbosch in a must win ABSA Premiership game.
Mosimane recalled Tebogo Langerman and Sphelele Mkhulise while Mosa Lebusa and Lebohang Maboe made their way to the bench.
The Brazilians took an early lead as Themba Zwane opened the scoring after some lovely interplay with Sibusiso Vilakazi left Stellies shot-stopper Lee Langeveldt with no chance from point blank range.
Downs were dealt a blow with Mkhulise limping off midway through the half as Lebohang Maboe was called to action.
Sundowns were forced to finish the game with 10 men when Tebogo Langerman was forced off due to knee injury and Mosimane having used all three substitutions.
Downs were left with hearts in their mouth as Denis Onyango forced a superb save in second-half stoppage time to deny Stellenbosch the equaliser.
The home side pushed hard but the Brazilians showed maturity and experience to close out the game.
Mamelodi Sundowns: Onyango, Ngcongca, Nascimento, Madisha, Langerman, Kekana, Jali, Sirino, Zwane, Vilakazi, Mkhulise.
Subs: Mweene, Lakay, Ngoma, Maboe, Lebusa, Mabunda Meza.
Stellenbosch: Langeveldt, Mobbie, Mbekile, De Goede, Mthethwa, Van Heerden, Scott, Msengi, Du Preez, Karuru, Skelem.
Subs: De Jong, Robertson, Bergman, Moroole, Rayners, Isaacs, Moon.