Mamelodi Sundowns and Bidvest Wits settled for a point each after playing to a 1-1 draw in their Absa Premiership match on Tuesday evening.
Mosimane made only one change to the team that lifted the Telkom Knockout cup over the weekend, with Lyle Lakay the only inclusion for the suspended Tebogo Langerman.
The Clever Boys started the game with a point to prove and Thulani Hlatshwayo squandered a chance early on.
Andile Jali continued to impress in the midfield dispossessing Thabang Monare to play a cross to the back-post for Themba Zwane, whose scuffed shot fell to Gaston Sirino who made no mistake firing the Brazilians into the lead.
Wits continued to press forward as Gift Motupa levelled matters with a minute to go, a powerful diving header from inside the box.
Thapelo Morena looked to restore the lead minutes after the restart, but Wits shot-stopper Ricardo Goss parried his effort wide to keep the Clever Boys in the game.
Mosimane rang the changes with ten minutes to full-time, as Keletso Makgalwa replaced Themba Zwane, as he looked for a late winner.
Downs continued to create chances in the final third but could not find the finishing touches as the game drew to a close with both sides sharing the spoils.
The Brazilians moving up to second spot in the Absa PSL log while Bidvest Wits find themselves in fourth position.